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They grew and examined the transfected cells for markers of HIV proliferation-such as RNA and proteins-and discovered that most of them had been with the capacity of creating these elements despite their mutations. The actual fact that defective proviruses can donate to viral RNA and proteins creation is concerning, since it implies that the measurements of HIV insert in infected individuals may possibly not be as accurate once we thought. Area of the count number is via defective infections, says Ho. After verifying that defective HIV proviruses created HIV proteins, the research workers then tested whether human disease fighting capability cells could biologically recognize and connect to those proteins.